Publications – Peer Reviewed

PEER REVIEWED PUBLICATIONS (2011-PRESENT)

2017

Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, John F. Valliant.* Technetium(I) Complexes of Bathophenanthroline Disulfonic Acid. Inorg. Chem. 2017; 56(5):2958–2965. DOI: 10.1021/acs.inorgchem.6b03058

Holly A. Bilton, Zainab Ahmad, Nancy Janzen, Shannon Czorny, John F. Valliant.* Preparation and Evaluation of 99mTc-labeled tridentate chelates for pre-targeting using bioorthogonal chemistry. J. Visual. Exp. 2017. 120: e55188. DOI: 10.3791/55188.

2016

Glenn Bauman, Peter Martin, Jonathan Thiessen, Reggie Taylor, Madeleine Moussa, Irina Rachinsky, Zahra Kassam, Joseph Chin, Stephen Pautler, T-Y Lee, John Valliant, Aaron Ward.   [18F]-DCFPyL PET/MRI for localization of dominant intra-prostatic foci: first experience.  Eur. Urol. Focus  (Oct., 2016)  DOI: 10.1016/j.euf.2016.10.002

Salma Al-Karmi, Silvia A. Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta,* John F. Valliant.* Preparation of a 18F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species. Chem. Eur. J. 2017; 23(2):254-258. DOI: 10.1002/chem.201604473.

Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R. Genady, Salma A. Al-Karmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J. Berti and John F. Valliant.* A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS One. 2016; 11(12):e016745. DOI: 10.1371/journal.pone.0167425.

Abdolreza Yazdani, Holly Bilton, Alyssa Vito, Afaf R. Genady, Stephanie M. Rathmann, Zainab Ahmad, Nancy Janzen, Shannon Czorny, Brian M. Zeglis, Lynn C. Francesconi, John F. Valliant.* A Bone-Seeking Trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines. J. Med. Chem. 2016; 59(20):9381-9389.  DOI: 10.1021/acs.jmedchem.6b00938.

John F. Valliant.* A Bridge Not Too Far. Linking Disciplines Through Molecular Imaging Probes. J. Nucl. Med. Technol. 2016:44(3):173-183. DOI: 10.2967/jnumed.109.068312.

Stephanie M. Rathmann, Nancy Janzen, John F. Valliant.* Synthesis, radiolabelling and biodistribution studies of triazole derivatives for targeting melanoma. Can. J. Chem. 2016; 94(9): 773-780. DOI: 10.1139/cjc-2016-0239

Lukas P. Sadowski, Patricia E. Edem, John F. Valliant,* Alex Adronov.* Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications. Macromol. Biosci. 2016; 16(10):1475-1484. DOI: 10.1002/mabi.201600154.

Vincent Bouvet, Melinda Wuest, Hans-Soenke Jans, Nancy Janzen, Afaf R. Genady, John F. Valliant, Francois Bernard, Frank Wuest.* Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models. Eur J NMMI Res. 2016; 6(1):1-15. DOI: 10.1186/s13550-016-0195-6.

Ole Tietz, James Dzandzi, Atul Bhardwaj, John F. Valliant, Frank Wuest.* Design and synthesis of [125I]Pyricoxib: A novel 125I-labeled cyclooxygenase-2 (COX-2) inhibitors. Bioorg. Med. Chem. Lett. 2016; 26(6):1516-1520. DOI: 10.1016/j.bmcl.2016.02.029.

Afaf Genady, Nancy Janzen, Laura Banevicius, Mahmoud El-Gamal, Mohamed El Zaria, John Valliant.* Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules that Target Prostate Specific Membrane Antigen (PSMA) for Combined Radiotherapy and Immunotherapy. J. Med. Chem. 2016;59(6):2660–2673. DOI: 10.1021/acs.jmedchem.5b01881.

Rosalyn A. Juergens,* Katherine A. Zukotynski, Amit Singnurkar, Denis P. Snider, John F. Valliant, Karen Y. Gulenchyn. Imaging Biomarkers in Immunotherapy.  Biomarkers Cancer. 2016; 8(S2):1-13. DOI: 10.4137/BIC.S31805.

Silvia A. Albu, Salma A. Al-Karmi, James P.K. Dzandzi, Aimen Zlitni, Denis Beckford-Vera, Alyssa Vito, Megan Blacker, Nancy Janzen, Ramesh M. Patel, Alfredo Capretta, John, F. Valliant.* 125I-Tetrazines and Inverse-Electron-Demand Diels-Alder Chemistry:  A Convenient Radioiodination Strategy for Biomolecular Labeling, Screening and Biodistribution Studies.  Bioconjugate Chem. 2016; 27(1):207-216.  DOI: 10.1021/acs.bioconjchem.5b00609.

2015

Schaffer, P.; Benard, F.; Bernstein, A.; Buckley, K.; Celler, A.; Cockburn, N.; Corsaut, J.; Dodd, M.; Economou, C.; Eriksson, T.; Frontera, M.; Hanemaayer, V.; Hook, B.; Klug, J.; Kovacs, M.; Prato, F.S.; McDiarmid, S.; Ruth, T.J.; Shanks, C.; Valliant, J.F.; Zeisler, S.; Zetterberg, U.; Zavodszky, P.A. Direct Production of 99mTc via 100Mo(p,2n) on Small Medical Cyclotrons. Physics Procedia. 2015; 66(23): 383-395.

Stuart A. McNelles, Spencer D. Knight, Nancy Janzen, J.F. Valliant*, Alex Adronov.* Synthesis, Radiolabeling, and In-Vivo Imaging of PEGylated High-Generation Polyester Dendrimers. Biomacromolecules. 2015; 16(9):3033-3041.

James P. K. Dzandzi, Denis R. Beckford Vera, Afaf R. Genady, Silvia A. Albu, Louise J. Eltringham-Smith, Alfredo Capretta, William P. Sheffield, John F. Valliant. Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis. J. Org. Chem. 2015; 80(14):7117-7125.

Afaf R. Genady, Joanne Tan, Mohamed E. El-Zaria, Aimen Zlitni, Nancy Janzen, John F. Valliant. Synthesis, Characterization and Radiolabeling of Carborane-Functionalized Tetrazines for Use in Inverse Electron Demand Diels-Alder Ligation Reactions. J. Organomet. Chem. 2015; 204-213.

Nilasha Banerjee, T. Robert Wu, Jason Chio, Ryan Kelly, Karin A. Stephenson, John Forbes, Christine Allen, John F. Valliant, Reina Bendayan. 125I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells Nuc. Med. Biol. 2015; 42(3)274-282.

Abdolreza Yazdani, Nancy Janzen, Laura Banevicius, Shannon Czorny, John F. Valliant. Imidazole-based [2+1] Re(I)/99mTc(I) Complexes as Isostructural Nuclear and Optical Probes. Inorg. Chem. 2015; 54(4):1728-1736.

2014

John F. Valliant, Patricia Edem, Shannon Czorny. Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B. J. Med. Chem. 2014; 57(22):9564‑9577.

James P. K. Dzandzi, Denis R. Beckford Vera, John F. Valliant.* A Hybrid Solid-Fluorous Phase Radioiodination and Purification Platform. J. Labelled Comp. Radiopharm. 2014; 57(9):551–557.

Mohamed E. El-Zaria, Kunal Keskar, Afaf R. Genady, Joseph A. Ioppolo, James McNulty, John F. Valliant. High Yielding Synthesis of Carboranes Under Mild Conditions Using a Homogeneous Silver(I) Catalyst. Direct Evidence of a Bimetallic Intermediate. Angew. Chem. Int. Ed. 2014; 53(20):5156-5160.

Aimen Zlitni, Nancy Janzen, F. Stuart Foster, John F. Valliant.* Catching Bubbles. Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse Electron Demand Diels-Alder Chemistry. Angewandte Chemie. 2014; 53(25):6459-6463.

Dong Hyun Kim, Megan Blacker, John F. Valliant.* Preparation and Evaluation of Fluorine-18 Labeled Insulin as a Molecular Imaging Probe for Studying Insulin Receptor Expression in Tumors. J. Med. Chem, 2014; 57(9):3678-3686.

Mohamed E. El-Zaria, Afaf R. Genady, Nancy Janzen, Christina I. Petlura, Denis R. Beckford Vera, John F. Valliant.* Preparation and Evaluation of Carborane-Derived Inhibitors of Prostate Specific Membrane Antigen (PSMA). Dalton Trans. 2014; 43(13):4911-5232.

Michael P. Coogan, Robert P. Doyle, John F. Valliant, John W. Babich, Jon Zubieta. Single amino acid chelate complexes of the M(CO)3+ core for correlating fluorescence and radioimaging studies (M = 99mTc or Re). J. Labelled Comp. Radiopharm. 2014; 57(4):255-261.

2013

Tamil Selvi Pitchumony, Laura Banevicius, Nancy Janzen, Jon Zubieta, John F. Valliant.* Isostructural Nuclear and Luminescent Probes Derived From Stabilized [2+1] Re(I)/Tc(I) Organometallic Complexes. Inorg. Chem. 2013; 52(23):13521-13528.

Antonio Toppino, Afaf R. Genady, Mohamed E. El-Zaria, James Reeve, Fargol Mostofian, Jeff Kent, John F. Valliant* High Yielding Preparation of Dicarba-closo-dodecaboranes Using a Silver(I) Mediated Dehydrogenative Alkyne-Insertion Reaction. Inorg. Chem. 2013; 52:8743-8749.

Kelly E. Henry, Rebeca G. Balasingham, Anthony R. Vortherms, James A. Platts, Michael P. Coogan, Jon Zubieta, Robert P. Doyle, John F. Valliant.* Emission wavelength variation with changes in excitation in a Re(i)-bisthiazole ligand complex that breaks the Kasha-Vavilov rule. Chemical Science 2013; 4:2490-2495.

2012

Mohamed El-Zaria, Nancy Janzen, John F. Valliant.* Room Temperature Synthesis of Re(I) and Tc(I) Metallocarboranes. Organometallics 2012; 31:5940-5949.

Mohamed E. El-Zaria, Nancy Janzen, Megan Blacker, John F. Valliant.* Synthesis, Characterization, and Biodistribution of Radiodinated C-Hydroxy-Carboranes. Chem. Eur. J. 2012; 18:11071-11078.

Anika Louie, Laura E. Harrington, John F. Valliant.* The Preparation and Characterization of Functionalized Carboranes and Re/Tc-Metallocarboranes as Platforms for Developing Molecular Imaging Probes: Structural and Cage Isomerism Studies. Inorg. Chim. Acta. 2012; 389:159-167.

Alla Darwish, Megan Blacker, Nancy Janzen, Stephanie M. Rathmann, Shannon K. Czorny, Shawn M. Hillier, John L. Joyal, John W. Babich, John F. Valliant.* Triazole Appending Agent (TAAG): A New Synthon for Preparing Iodine-Based Molecular Imaging and Radiotherapy Agents. Med. Chem. Lett. 2012; 3:313-316.

Ryan W. Simms, Patrick W. Causey, Darren M. Weaver, Chitra Sundararajan, Karin A. Stephenson, John F. Valliant.* Preparation of Technetium-99m Bifunctional Chelate Complexes Using a Microfluidic Reactor: A Comparative Study with Conventional and Microwave Labelling Methods. J. Labelled Comp. Rad. 2012; 55:18-22.

Ryan W. Simms, Dong Hyun Kim, Darren M. Weaver, Chitra Sundararajan, Megan Blacker, Karin A. Stephenson, John F. Valliant,* Emulsion Reactors: A New Technique for the Preparation of Molecular Imaging Probes. Chem. Eur J. 2012; 18:6746-6749.

2011

Neva Lazarova, Patrick W. Causey, Jennifer A. Lemon, Shannon K. Czorny, John R. Forbes, Aimen Zlitni, Afaf Genady, Stuart F. Foster, John F. Valliant.* The Synthesis, Magnetic Purification and Evaluation of 99m Tc-labeled Microbubbles. Nucl. Med. Biol. 2011; 38:1111-1118.

Jacqueline A. Gleave, John F. Valliant, Laurie Doering.* 99mTc-based Imaging of Transplanted Neural Stem Cells and Progenitor Cells. J. Nucl. Med. Technol. 2011; 39:114-120.

Henrik Braband, Yuji Tooyama, Thomas Fox, Ryan Simms, John Forbes, John F. Valliant, Roger Alberto.* fac-[TcO3(tacn)]+: A Versatile Precursor for the Labelling of Pharmacophores, Amino Acids and Carbohydrates through a New Ligand-Centred Labelling Strategy. Chem. Eur J. 2011; 17:12967-12974.

Anika S. Louie, Neil Vasdev, John F. Valliant.* Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors. J. Med. Chem. 2011; 54:3360-3367.

Justin W. Hicks, Laura E. Harrington, John F. Valliant.* Fluorous Ligand Capture (FLC): A Chemoselective Solution-phase Strategy for Isolating 99mTc-labelled Compounds in High Effective Specific Activity. Chem. Commun. 2011; 47:7518-7520.

Amanda C. Donovan, John F. Valliant.* Preparation and Evaluation of Reagents for Tagging Amino and Thiol Groups with Fluorous Stannanes. A Convenient Method for Producing Radioiodinated Compounds in High Effective Specific Activity. J. Labelled Comp. Rad. 2011; 54:65-71.